Comparison of Lutetium-177 tin colloid and Rhenium-188 tin colloid radiosynovectomy in chronic knee arthritis.

Title Comparison of Lutetium-177 tin colloid and Rhenium-188 tin colloid radiosynovectomy in chronic knee arthritis.
Authors S.Ahmed Shamim; G. Arora; P. Jha; P. Gupta; A. Behera; A. Mukherjee; M. Prabhu; M.Tahir Ansari; S. Vyas; C. Bal
Journal Nucl Med Commun
DOI 10.1097/MNM.0000000000001210
Abstract

OBJECTIVE: To assess the role of Lutetium-177(Lu-177) tin colloid for radiosynovectomy and compare it with Rhenium-188 (Re-188) tin colloid radiosynovectomy for alleviation of pain in patients with chronic inflammatory arthritis of knee.

METHODS: Patients of chronic inflammatory arthritis of the knee underwent pretherapeutic evaluation in a form of knee ultrasonogram, bone scan and clinical evaluation. Fifty-seven recruited patients were allocated at random to receive either intraarticular injections of Lu-177 tin colloid or Re-188 tin colloid. Eventually, 27 patients received Re-188 tin colloid and 30 patients received Lu-177 tin colloid. The joint was then immobilized for 2?days. Response evaluation was done using knee ultrasound, bone scan and clinical findings.

RESULT: Of 30, 20 patients responded to radiosynovectomy in the Lu-177 tin colloid group compared to 21/27 patients in the Re-188 tin colloid group.

CONCLUSION: Lu-177 tin colloid is an effective alternative to Re-188 tin colloid for radiosynovectomy in patients with chronic inflammatory knee arthritis.

Citation S.Ahmed Shamim; G. Arora; P. Jha; P. Gupta; A. Behera; A. Mukherjee; M. Prabhu; M.Tahir Ansari; S. Vyas; C. Bal.Comparison of Lutetium-177 tin colloid and Rhenium-188 tin colloid radiosynovectomy in chronic knee arthritis.. Nucl Med Commun. 2020. doi:10.1097/MNM.0000000000001210

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Rhenium

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