Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease.

Title Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease.
Authors G. Sánchez-Elexpuru; J.M. Serratosa; M.P. Sánchez
Journal Epilepsia
DOI 10.1111/epi.13656
Abstract

OBJECTIVE: To search for new therapies aimed at ameliorating the neurologic symptoms and epilepsy developing in patients with Lafora disease.

METHODS: Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes. Epm2a(-/-) and Epm2b(-/-) mice display neurologic and behavioral abnormalities similar to those found in patients. Selenium is a potent antioxidant and its deficiency has been related to the development of certain diseases, including epilepsy. In this study, we investigated whether sodium selenate treatment improved the neurologic alterations and the hyperexcitability present in the Epm2b(-/-) mouse model.

RESULTS: Sodium selenate ameliorates some of the motor and memory deficits and the sensitivity observed with pentylenetetrazol (PTZ) treatments in Epm2b(-/-) mice. Neuronal degeneration and gliosis were also diminished after sodium selenate treatment.

SIGNIFICANCE: Sodium selenate could be beneficial for ameliorating some symptoms that present in patients with Lafora disease.

Citation G. Sánchez-Elexpuru; J.M. Serratosa; M.P. Sánchez.Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease.. Epilepsia. 2017;58(3):467475. doi:10.1111/epi.13656

Related Elements

Sodium

Sodium Bohr ModelSee more Sodium products. Sodium (atomic symbol: Na, atomic number: 11) is a Block D, Group 5, Period 4 element with an atomic weight of 22.989769. The number of electrons in each of Sodium's shells is [2, 8, 1] and its electron configuration is [Ne] 3s1. The sodium atom has a radius of 185.8 pm and a Van der Waals radius of 227 pm. Sodium was discovered and first isolated by Sir Humphrey Davy in 1807. In its elemental form, sodium has a silvery-white metallic appearance. It is the sixth most abundant element, making up 2.6 % of the earth's crust. Sodium does not occur in nature as a free element and must be extracted from its compounds (e.g., feldspars, sodalite, and rock salt). The name Sodium is thought to come from the Arabic word suda, meaning "headache" (due to sodium carbonate's headache-alleviating properties), and its elemental symbol Na comes from natrium, its Latin name.

Selenium

Selenium Bohr ModelSee more Selenium products. Selenium (atomic symbol: Se, atomic number: 34) is a Block P, Group 16, Period 4 element with an atomic radius of 78.96. The number of electrons in each of Selenium's shells is 2, 8, 18, 6 and its electron configuration is [Ar] 3d10 4s2 4p4. The selenium atom has a radius of 120 pm and a Van der Waals radius of 190 pm. Selenium is a non-metal with several allotropes: a black, vitreous form with an irregular crystal structure three red-colored forms with monoclinic crystal structures and a gray form with a hexagonal crystal structure, the most stable and dense form of the element. Elemental SeleniumOne of the most common uses for selenium is in glass production the red tint that it lends to glass neutralizes green or yellow tints from impurities in the glass materials. Selenium was discovered and first isolated by Jöns Jakob Berzelius and Johann Gottlieb Gahn in 1817. The origin of the name Selenium comes from the Greek word "Selênê," meaning moon.

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